Romance languages tend to use the form sancta sanctorum, treating it as masculine and singular.

The Latin word sanctum may be used in English, following Latin, for 'a holy place', or a sanctuary, as in the novel Jane Eyre (1848) which refers to 'the sanctum of school room'. Thus the term sanctum sanctorum literally means 'the holy of the holy ', replicating in Latin the Hebrew construction for the superlative, with the intended meaning 'the most holy '. The Latin word sanctum is the neuter form of the adjective ' holy', and sanctorum its genitive plural. In Hinduism, a temple's innermost part where the Murti of the deity is kept forms the Garbha griha, also referred to as a sanctum sanctorum. Hence the derivative usage to denote the Sancta Sanctorum chapel in the complex of the Archbasilica of Saint John Lateran, Rome. The Vulgate translation of the Bible uses sancta sanctorum for the Holy of Holies. The plural form sancta sanctorum is also used, arguably as a synecdoche, referring to the holy relics contained in the sanctuary. The Latin phrase sanctum sanctorum is a translation of the Hebrew term קֹדֶשׁ הַקֳּדָשִׁים (Qṓḏeš HaQŏḏāšîm), literally meaning Holy of Holies, which generally refers in Latin texts to the holiest place of the Ancient Israelites, inside the Tabernacle and later inside the Temple in Jerusalem, but the term also has some derivative use in application to imitations of the Tabernacle in church architecture. Translation of the Hebrew term Qṓḏeš HaQŏḏāšîm (Holy of Holies

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